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Emmanuel Normant Selected Research

tanespimycin (17AAG)

11/2013A phase I study of the HSP90 inhibitor retaspimycin hydrochloride (IPI-504) in patients with gastrointestinal stromal tumors or soft-tissue sarcomas.
5/2012Heat shock protein 90 is a promising target for effective growth inhibition of gastrointestinal neuroendocrine tumors.
12/2011A phase 1 study of IPI-504 (retaspimycin hydrochloride) in patients with relapsed or relapsed and refractory multiple myeloma.
10/2011The heat shock protein 90 inhibitor IPI-504 induces KIT degradation, tumor shrinkage, and cell proliferation arrest in xenograft models of gastrointestinal stromal tumors.
9/2011Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors.
9/2011The Novel HSP90 inhibitor, IPI-493, is highly effective in human gastrostrointestinal stromal tumor xenografts carrying heterogeneous KIT mutations.
5/2011Antitumor activity of the Hsp90 inhibitor IPI-504 in HER2-positive trastuzumab-resistant breast cancer.
1/2011The Hsp90 inhibitor IPI-504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP/Grp78.
12/2010Hsp90 (heat shock protein 90) inhibitor occupancy is a direct determinant of client protein degradation and tumor growth arrest in vivo.
12/2009The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo.
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Emmanuel Normant Research Topics

Disease

14Neoplasms (Cancer)
11/2020 - 07/2006
3Multiple Myeloma
11/2020 - 05/2008
2B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
12/2021 - 11/2020
2Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
11/2014 - 08/2014
2Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
11/2013 - 10/2011
2Necrosis
10/2011 - 09/2011
1Non-Hodgkin Lymphoma (Lymphosarcoma)
12/2021
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
11/2020
1Hematologic Neoplasms (Hematological Malignancy)
11/2020
1Lymphoma (Lymphomas)
11/2020
1Carcinogenesis
11/2020
1Myelodysplastic Syndromes (Myelodysplastic Syndrome)
11/2020
1B-Cell Lymphoma (Lymphoma, B Cell)
11/2016
1Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
11/2014
1Sarcoma (Soft Tissue Sarcoma)
11/2013
1Neuroendocrine Tumors (Neuroendocrine Tumor)
05/2012
1Insulinoma
05/2012
1Carcinoid Tumor (Carcinoid)
05/2012
1Breast Neoplasms (Breast Cancer)
05/2011
1Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
01/2011

Drug/Important Bio-Agent (IBA)

13tanespimycin (17AAG)IBA
11/2013 - 07/2006
7Heat-Shock Proteins (Heat-Shock Protein)IBA
11/2013 - 07/2006
6Proteins (Proteins, Gene)FDA Link
11/2020 - 07/2006
2Phosphotransferases (Kinase)IBA
11/2020 - 08/2014
2Proteasome InhibitorsIBA
01/2011 - 11/2006
2Bortezomib (Velcade)FDA Link
01/2011 - 11/2006
2Biological ProductsIBA
01/2009 - 11/2006
1Biomarkers (Surrogate Marker)IBA
12/2021
1RNA (Ribonucleic Acid)IBA
12/2021
1Casein Kinase I (Casein Kinase 1)IBA
11/2020
1Protein Isoforms (Isoforms)IBA
11/2020
1Chemotactic FactorsIBA
01/2020
1Chemokine CCL3IBA
01/2020
1CytokinesIBA
01/2020
1Histone MethyltransferasesIBA
11/2016
1(R)- N- ((4- methoxy- 6- methyl- 2- oxo- 1,2- dihydropyridin- 3- yl)methyl)- 2- methyl- 1- (1- (1- (2,2,2- trifluoroethyl)piperidin- 4- yl)ethyl)- 1H- indole- 3- carboxamideIBA
11/2016
1Lysine (L-Lysine)FDA Link
11/2016
1Histones (Histone)IBA
11/2016
1Polycomb Repressive Complex 2IBA
11/2016
1Enhancer of Zeste Homolog 2 ProteinIBA
11/2014
1Histone-Lysine N-MethyltransferaseIBA
11/2014
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
10/2011
1Sirolimus (Rapamycin)FDA Link
09/2011
1Trastuzumab (Herceptin)FDA Link
05/2011
1Endoplasmic Reticulum Chaperone BiPIBA
01/2011
1Pharmaceutical PreparationsIBA
12/2010
1quinone (benzoquinone)IBA
12/2009
1EnzymesIBA
12/2009
1hydroquinone (Esoterica)FDA Link
12/2009
1Rifabutin (Ansamycin)FDA Link
01/2009

Therapy/Procedure

1Therapeutics
09/2011
1Heterologous Transplantation (Xenotransplantation)
01/2011
1Aftercare (After-Treatment)
12/2010